Autonomic nervous system influences on qt interval in normal subjects

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Autonomic nervous system influences on QT interval in normal subjects.

OBJECTIVES We sought to determine whether the relationship between heart rate (HR) and QT interval (QT) differs as HR increases in response to exercise, atropine and isoproterenol. BACKGROUND Autonomic nervous system influences on repolarization are poorly understood and may complicate the interpretation of QT measurements. METHODS Twenty-five normal subjects sequentially underwent graded-i...

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Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity

AIM To examine the impact of liver cirrhosis on QT interval and cardiac autonomic neuropathy (CAN). METHODS A total of 51 patients with cirrhosis and 51 controls were examined. Standard 12-lead electrocardiogram recordings were obtained and QT as well as corrected QT interval (QTc) and their dispersions (dQT, dQTc) were measured and calculated using a computer-based program. The diagnosis of ...

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Influence of age, the autonomic nervous system and anxiety on QT-interval variability.

As QT variability increases and heart rate variability diminishes, the QT variability index (QTVI) - a non-invasive measure of beat-to-beat fluctuations in QT interval on a single ECG lead - shows a trend towards positive values. Increased QT variability is a risk factor for sudden death. Aging lengthens the QT interval and reduces RR-interval variability. In the present study we investigated t...

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Modulation of QT interval during autonomic nervous system blockade in humans.

BACKGROUND It is thought that the autonomic nervous system modulates QT interval, but traditional autonomic blockade combining propranolol and atropine has produced conflicting results. We used the alternative approach of interrupting neurotransmission at the level of autonomic ganglia to determine its effect on the QT interval. METHODS AND RESULTS We infused trimethaphan at increasing doses ...

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Diurnal variation of the QT interval--influence of the autonomic nervous system.

To assess the influence of diurnal changes in the autonomic nervous system on the QT interval, 24 hour dynamic electrocardiographic monitoring was performed in six pacemaker dependent patients with normally innervated hearts, in six cardiac transplant patients with anatomically denervated hearts (but which respond to circulating catecholamines), and in nine diabetic patients with confirmed auto...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2002

ISSN: 0735-1097

DOI: 10.1016/s0735-1097(02)01852-1